ОПИОИДНАЯ СИСТЕМА И АДАПТАЦИЯ К ГИПОКСИИ
Обзор посвящен анализу роли опиодных рецепторов, их эндогенных и синтетических агонистов в формировании устойчивости организма к действию острой гипоксии. Приводятся данные о том, что стимуляция опиоидных рецепторов сопровождается нейропротекторным эффектом при острой гипоксии. Рассматривается роль различных типов опиоидных рецепторов в реализации защитного действия адаптации к гипоксии. Анализируются сведения о механизмах действия опиоидов, роли цАМФ, цГМФ, оксида азота, инозитолтрифосфата, К+ - и Са2+ - каналов в реализации эффектов агонистов опиоидных рецепторов. Обсуждаются опиоидергические механизмы, обеспечивающие повышенную устойчивость сердца к последствиям острой кислородной недостаточности.
Ключевые слова: опиоидные рецепторы, опиоидная система, КАТР-каналы, цАМФ, цГМФ, инозитолтрифосфат, оксид азота, гипоксия, адаптация
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Рубрика: Biology
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