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ROLE OF M-OPIOID RECEPTORS IN THE REGULATION OF ISOLATED HEART RESISTANCE TO ISCHEMIA AND REPERFUSION // Tomsk State Pedagogical University Bulletin. 2009. Issue 3 (81). P. 7-11

It was studied effect of activation of M-opioid receptor (OR) on the tolerance of isolated perfused rat heart to global 45 min ischemia and 30 min reperfusion. In vivo pretpeatment with selective M-opioid receptor agonist DAMGO (0,1mg/kg intravenously) increased tolerance of isolated perfused rat heart to ischemia and reperfusion. This effect was completely abolished by pretreatment with the M-antagonist CTAP. Addition of DAMGO and DALDA to the perfusion solution in a final concentration of 170 nМ before ischemia had no cardioprotective effect. However, addition of DALDA to the perfusion solution in a final concentration of 33 nM also decreased creatine kinase levels in the coronary sinus effluent.

Keywords: M-оpioid receptors, isolated heart, ischemia, reperfusion

OPIOID RECEPTORS AGONISTS MIMIC PRECONDITIONING OF THE HEART: THE ROLE OF CYCLIC NUCLEOTIDES AND CA2+-ATP-ASE OF SARCOPLASMIC RETICULUM // Tomsk State Pedagogical University Bulletin. 2010. Issue 3 (93). P. 64-69

It has been found that occupancy of and ^-opioid receptors (ORs) by DPDPE and U-50488, respectively, prevents irreversible cardiac cell damage during global ischemia (45 min) and reperfusion (30 min) of the isolated perfused rat heart by the Langendorff technique. Activation of Kj-ORs decreased cAMP levels in the myocardium during reperfusion but stimulation of 8J-ORs had no effect on the cAMP levels. The occupancy of both types of receptors did not alter the cGMP levels before and after ischemia. Cardioprotective effect of DPDPE was completely abolished by pretreatment with cyclopiazonic acid, an inhibitor of Ca2+-ATPase of sarcoplasmic reticulum. Authors proposed that cardioprotective effect of U-50488 is mediated via a decrease in cAMP levels in the heart but cardioprotective effect of DPDPE is depended on the activity of Ca2+-ATPase of sarcoplasmic reticulum.

Keywords: isolated perfused rat heart, ischemia, reperfusion, opioid receptors

OPIOID SYSTEM AND ADAPTATION TO HYPOXIA // Tomsk State Pedagogical University Bulletin. 2011. Issue 8 (110). P. 109-114

The paper deals with the analysis of opioid receptors, their endogenous and synthetic agonists in the formation of resistance to acute hypoxia. The article proves that stimulation of opioid receptors is normally accompanied by a neuroprotective effect in acute hypoxia. It also studies the role of different types of opioid receptors in the implementation of the adaptation protective effect to hypoxia. Mechanisms opioids activity, the role of cAMP, cGMP, nitric oxide, inositol triphosphate, K+ - and Ca2 + -channels in implementation of agonists effects of opioid receptors are analysed. Opioidergic mechanisms of the reactions that increase the resistance to hypoxia are described.

Keywords: opioid receptors, opioid system, КАТР-channels, cAMP, cGMP, inositoltriphosphate, nitric oxide, hypoxia, adaptation.

EFFECT OF CANNABINOID RECEPTOR AGONISTS ON THE CARDIAC RESISTANCE TO IMPACT OF ISCHEMIA AND REPERFUSION // Tomsk State Pedagogical University Bulletin. 2012. Issue 7 (122). P. 116-121

In experiments with isolated perfused rat heart it was investigated cardioprotective effect of the selective and the nonselective cannabinoid receptor agonists during ischaemia and reperfusion at the final concentration of 0.1 and 1.0 mM. It was established that the CB1 agonist ACPA, the CB1- and CB2-receptor agonist HU-210 and the CB1- and CB2-receptor agonist СР 55,940 exhibit cardioprotective effect. The selective CB2-agonist JWH133 and the CB1- and CB2-receptor agonists anandamide and methanandamide did not exhibit cytoprotective effect. Cardioprotective effect HU-210 is depended on the activation of CB1-cannabinoid receptor.

Keywords: Cannabinoid receptors, isolated heart

EFFECT OF ULTRAFINE POWDERS OF PIEZOELECTRIC CERAMICS FOR SOME BLOOD PARAMETERS IN RATS DURING THEIR LONG-TERM CHRONIC EXPOSURE // Tomsk State Pedagogical University Bulletin. 2012. Issue 7 (122). P. 122-128

The article presents experimental data on the effect of lithium hexafluorophosphate and ultradispers pezokeramik powders based on lead zirconate titanate on blood parameters in rats with long-term chronic exposure. The development revealed depression of quantitative parameters of blood after the application of lithium hexafluoride, disorganization of surface architectonics of erythrocytes under the influence of ultrafine powders of lead zirconate titanate.

Keywords: erythrocytes, reticulocytes, neutrophils, lymphocytes, monocytes, hexafluorophosphate lithium soot pezokeramiki lead zirconate titanate

CORRECTION OF ENERGY METABOLISM IMPRAIMENTS IN TETRACHLORMETHANE-POISONED RAT LIVER TISSUE BY MEANS OF SAPROPEL LIPIDS // Tomsk State Pedagogical University Bulletin. 2013. Issue 8 (136). P. 94-99

Energy metabolism was studied in poisoned rat liver tissue after application of sapropel lipid extracts and its fractions. Total extract and its polar fractions affected distinctly the energy metabolism and ultrastructure of hepatocytes. The restoring influence of sapropel lipids appears to occur due to hoth their chemical composition and adaptogenic effect on intracellular reparation.

Keywords: liver, sapropel, lipids, ultrastructure of hepatocytes

EFFICIENCY OF THE LYMPHATIC DRAINAGE MASSAGE AS REHABILITATION MEANS IN SKIING // Tomsk State Pedagogical University Bulletin. 2013. Issue 12 (140). P. 210-214

Efficiency of the lymphatic drainage massage of the lower limbs in comparison with a classical massage is studied in the article. A greater reduction effect of a lymphatic drainage massage in a pre-contest period of skiers is revealed.

Keywords: rehabilitation means, lymphatic drainage massage, skiing

THE OPIOID SYSTEM AND ITS POSSIBLE ROLE IN ADAPTATION TO HYPOXIA // Tomsk State Pedagogical University Bulletin. 2013. Issue 12 (140). P. 215-221

The present article reviews the role of opioid receptors and their endogenous and synthetic agonists in the formation of resistance to the action of condition of acute hypoxia. It shows that stimulation of opioid receptors is accompanied by a neuroprotective effect in acute hypoxia. It examines the role of different types of opioid receptors in the implementation of the protective effect of adaptation to hypoxia. The authors analyzed the results on the mechanisms of action of opioids, the role of cAMP, cGMP, nitric oxide, inositol triphosphate, K+- and Ca2+-channels in realization of the effects of agonists of opioid receptors. It discussed opioidergic mechanisms of the reactions that increase the resistance to hypoxia.

Keywords: opioid receptors, opioid system, КАТР-channels, cAMP, cGMP, inositoltriphosphate, nitric oxide, hypoxia, adaptation

STABILITY OF BODY REGULATORY SYSTEMS IN HEALTH AND FITNESS ACTIVITIES FOR CHILDREN // Tomsk State Pedagogical University Bulletin. 2013. Issue 12 (140). P. 227-231

This article explores the concept of the integrated assessment of the body functionality with an emphasis put on the involvement of regulatory systems in health and fitness activities for children.

Keywords: physical training, adaptive capacity, children

OPTIMIZATION OF THE PHYSICAL EXERTION DURING THERAPEUTIC PHYSICAL TRAINING FOR HYPERTENSIVE PATIENTS // Tomsk State Pedagogical University Bulletin. 2015. Issue 3 (156). P. 232-237

The article deals with the possibility of optimization of physical activity for hypertensive patients in a hospital during therapeutic physical training using electromagnetic radiation in the optical range. For this purpose was applied radiation with a wavelength of 420–480 nm (blue light) before a class of medical physical culture, which helped to harmonize interconnection, to reduce the risk of pathological reactions to greater physical activity. It is shown that the integrated application of these methods improves the efficiency of the rehabilitation process.

Keywords: electromagnetic radiation in the optical range, hypertension