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ROLE OF M-OPIOID RECEPTORS IN THE REGULATION OF ISOLATED HEART RESISTANCE TO ISCHEMIA AND REPERFUSION // Tomsk State Pedagogical University Bulletin. 2009. Issue 3 (81). P. 7-11

It was studied effect of activation of M-opioid receptor (OR) on the tolerance of isolated perfused rat heart to global 45 min ischemia and 30 min reperfusion. In vivo pretpeatment with selective M-opioid receptor agonist DAMGO (0,1mg/kg intravenously) increased tolerance of isolated perfused rat heart to ischemia and reperfusion. This effect was completely abolished by pretreatment with the M-antagonist CTAP. Addition of DAMGO and DALDA to the perfusion solution in a final concentration of 170 nМ before ischemia had no cardioprotective effect. However, addition of DALDA to the perfusion solution in a final concentration of 33 nM also decreased creatine kinase levels in the coronary sinus effluent.

Keywords: M-оpioid receptors, isolated heart, ischemia, reperfusion