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DEVELOPMENT MODEL OF BIOLOGICAL SYSTEMS TO ASSESS THE SEVERITY OF ORGANISM CONDITION AT AML - HEPATIC CHOLESTASIS (IN E PERIMENT IN VITRO) // Tomsk State Pedagogical University Bulletin. 2015. Issue 2 (155). P. 221-228

The article is devoted to the obstructive cholestasis – a type of violation of the outflow of bile from the liver (cholestasis), which is quite common in the clinical practice. An urgent problem is that of evaluation of its degree on the basis of diagnostic systems of marker indicators of metabolic status of the organism (static and dynamic), one of the leading may be the antioxidant activity and the level of oxidative modification of proteins, in combination with the average mass of the molecules – a universal test of the severity of endotoxemia. For such experimental studies (in vitro) it is suitable to develop model biological systems, which will allow to test the sensitivity of the studied metabolic tests to varying degrees of severity of subhepatic cholestasis and in the future – to create diagnostic systems on their basis.

Keywords: obstructive cholestasis, modeling biological systems, oxidative modification of proteins, the molecules of average weight