THE OPIOID SYSTEM AND ITS POSSIBLE ROLE IN ADAPTATION TO HYPOXIA
The present article reviews the role of opioid receptors and their endogenous and synthetic agonists in the formation of resistance to the action of condition of acute hypoxia. It shows that stimulation of opioid receptors is accompanied by a neuroprotective effect in acute hypoxia. It examines the role of different types of opioid receptors in the implementation of the protective effect of adaptation to hypoxia. The authors analyzed the results on the mechanisms of action of opioids, the role of cAMP, cGMP, nitric oxide, inositol triphosphate, K+- and Ca2+-channels in realization of the effects of agonists of opioid receptors. It discussed opioidergic mechanisms of the reactions that increase the resistance to hypoxia.
Keywords: opioid receptors, opioid system, КАТР-channels, cAMP, cGMP, inositoltriphosphate, nitric oxide, hypoxia, adaptation
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Issue: 12, 2013
Series of issue: Issue 12
Rubric: THEORY AND METHODS OF PHYSICAL TRAINING AND SPORTS
Pages: 215 — 221
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